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Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer

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Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer

This slide set is based on a comparative effectiveness review (CER) titled, Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer, that was developed by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center for the Agency for Healthcare Research and Quality (AHRQ Contract No. 290-02-0026) and is available online at effectivehealthcare.ahrq.gov. CERs represent comprehensive systematic reviews of the literature and usually compare two or more types of treatment, such as different drugs, for the same disease. For the CER on radiotherapy treatment for head and neck cancer, primary clinical trials were identified from searches of MEDLINE® (January 1, 1990 through September 28, 2009), EMBASE®  (January 1, 1990 through September 28, 2009), and the Cochrane Central Register of Controlled Trials (no date restriction). This CER included 35 comparative studies: 32 observational nonrandomized studies, and 3 head-to-head randomized trials of intensity-modulated radiation therapy (IMRT), three-dimensional conformal radiation therapy (3DCRT), and two-dimensional radiation therapy (2DCT). Fifty-one single-arm studies were analyzed separately from the comparative studies (51 for IMRT, 18 for 3DCRT).