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Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care

Slide: 31 of 36

Overview of rFVIIa Use for Pediatric Cardiac Surgery

A total of 40 patients received rFVIIa prophylaxis in one poor-quality RCT (the only included study). This yielded an insufficient strength of evidence and fair applicability for the population targeted—infant patients with congenital heart defects requiring surgical repair. Current evidence is insufficient for comparing the harms and benefits of rFVIIa use in infant patients undergoing cardiac surgery for congenital heart defect repair. The importance and nature of interactions between rFVIIa administration, extracorporeal membrane oxygenation use, and the risk of thromboembolic events remain uncertain.