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Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care

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Relative Hematoma Expansion Is Reduced After rFVIIa Use in Spontaneous Intracranial Hemorrhage

Meta-analysis demonstrated significant reductions in the relative hematoma expansion for patients in the rFVIIa group when compared to the usual care group at all dosing levels. While the large Mayer 2005 study reported a significant dose-response effect of reduced hematoma growth with higher doses of rFVIIa, statistical tests for differences between dosing levels in our meta-analyses found no significant dose effect.