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Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care

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Comparative Studies on Off-Label rFVIIa Use

There were 24 randomized clinical trials (RCTs) and 31 comparative observational studies (COSs) available on rFVIIa use across a variety of clinical treatments. rFVIIa use in cardiac surgery (12 studies), trauma (9 studies), intracranial hemorrhage (8 studies), liver transplantation (8 studies), and other liver disease (5 studies) accounted for 57 percent of the 74 included studies. Thus, the focus of the review on rFVIIa use for intracranial hemorrhage, trauma, and cardiac surgery is justified by the prevalence of these uses.