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Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care

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Clinical Questions Addressed by the Comparative Effectiveness Review

The report titled, Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care, addressed the following clinical questions: (1) From an overview of real-world patterns of rFVIIa use and available comparative studies, which clinical populations are receiving off-label rFVIIa and which populations have been scientifically examined, and what are the characteristics of comparative studies evaluating off-label rFVIIa use?; and (2) What are the benefits and harms of using rFVIIa for selected off-label indications in patients with/undergoing: spontaneous intracranial hemorrhage, acquired coagulopathic massive bleeding from body trauma, bleeding from brain trauma, adult cardiac surgery, pediatric cardiac surgery, liver transplantation, or prostatectomy?