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Future Research Needs - Methods Research Series

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Overview – Sept. 13, 2010

Future Research Needs Projects

Comparative Effectiveness Reviews, systematic reviews of existing research on the effectiveness, comparative effectiveness, and comparative harms of different health care interventions, are intended to provide relevant evidence to inform real-world health care decisions for patients, providers, and policymakers.

An important part of these reviews is to not only synthesize the evidence, but also to identify the gaps in evidence that limited the ability to answer the systematic review questions. As part of a new effort in 2010, AHRQ supports EPCs to work with various stakeholders to further develop and prioritize the future research needed by decisionmakers.

This collection of Future Research Needs projects is intended to be used by researchers and funders of research to help improve the body of comparative effectiveness evidence that would be useful for decisionmakers.

Because this collection is new and there is no previous established methodology, two concurrent strategies will be employed:

  • The EPCs will pilot various methods for identifying and prioritizing evidence needs within certain topic areas. Published abstracts of the pilot studies can be accessed in the right navigation. Abstracts in development are listed below.
  • Research on various methodologic issues will complement these experiences and inform eventual guidance on approaches to determine and prioritize future research needs. To view the abstracts on various methodological issues, please see Future Research Needs – Methods Research Series.

Future Research Needs projects will be posted on this Web site and available for public comment for approximately 4 weeks. Comments will be reviewed and considered for incorporation into an updated report. If you would like to be notified of the publication of the Future Research Needs reports, please Join our E-mail List.

Comments and suggestions on the Future Research Needs projects can be made at Contact the Effective Health Care Program. Please include the title of the project in the comments box.

Future Research Needs Projects

No. 1: Comparative Effectiveness of Percutaneous Coronary Interventions and Coronary Artery Bypass Grafting for Patients with Coronary Artery Disease. View final report.

No. 2: Future Research Needs for the Treatment of Common Hip Fractures. View final report.

No. 3: Future Research Needs for the Integration of Mental Health/Substance Abuse and Primary Care. View final report.

No. 4: Future Research Needs for Comparative Effectiveness of Treatments of Localized Prostate Cancer. View final report.

No. 5: Future Research Needs To Reduce the Risk of Primary Breast Cancer in Women. View final report.

No. 6: Future Research Needs for Outcomes of Weight Gain in Pregnancy. View final report.

No. 7: Future Research Needs for the Management of Gestational Diabetes. View final report.

No. 8: Future Research Needs for Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard Medical Therapy for Treating Stable Ischemic Heart Disease. View final report.

No. 9: Future Research Needs for Attention Deficit Hyperactivity Disorder: Effectiveness of Treatment in At-Risk Preschoolers; Long-Term Effectiveness in All Ages; and Variability in Prevalence, Diagnosis, and Treatment. View final report.

No. 10: Future Research Needs for Hematopoietic Stem-Cell Transplantation in the Pediatric Population. View final report.

No. 11: Future Research Needs for Diagnosis of Obstructive Sleep Apnea. View the final report.

No. 12: Future Research Needs for Treatment of Obstructive Sleep Apnea. View final report.

No. 13: Future Research Needs for First- and Second- Generation Antipsychotics for Children and Young Adults. View final report.

No. 14: Future Research Needs for Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), or Direct Renin Inhibitors (DRIs) for Treating Hypertension. View final report.

No. 15: Vaginal Birth After Cesarean: Developing and Prioritizing a Future Research Agenda. View final report.

No. 16: Self-Measured Blood Pressure: Future Research Needs. View final report.

No. 17: Future Research Needs for Prevention and Treatment of Clostridium difficile Infection. View final report.

No. 18: Future Research Needs for the Comparative Effectiveness of Breathing Exercises and/or Retraining Techniques in the Treatment of Asthma. View final report.

No. 19: Future Research Needs for Noncyclic Chronic Pelvic Pain Therapies for Women. View final report.

No. 20: Future Research Needs: Interventions for Adolescents and Young Adults With Autism Spectrum Disorders. View final report.

No. 21: Adjuvant Treatment for Phenylketonuria: Future Research Needs. View final report.

No. 22: Future Research Needs for Strategies To Reduce Cesarean Birth in Low-Risk Women. View final report.

No. 23: Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias: Future Research Needs. View final report.

No. 24: PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs. View final report.

No. 25: Intravascular Diagnostic Procedures and Imaging Techniques Versus Angiography Alone in Coronary Stenting: Future Research Needs. View final report.

No. 26: Pharmacological Management of Crohn's Disease: Future Research Needs.View final report.

No. 27: Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs. View final report.

No. 28: Treatment of Hepatitis C Virus Infection in Adults: Future Research Needs. View final report.

No. 29: Future Research Needs on Procalcitonin-Guided Antibiotic Therapy. View final report.

No. 30: Outpatient Case Management for Adults With Medical Illnesses and Complex Care Needs: Future Research Needs. View final report.

No. 31: Future Research Needs for Childhood Obesity Prevention Programs. View final report.

No. 32: Insulin Delivery and Glucose Monitoring Methods: Future Research Needs. View final report.

No. 33: Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease: Future Research Needs. View final report.

No. 34: Chronic Venous Leg Ulcer Treatment: Future Research Needs. View final report.

No. 35: Preventive Pharmacological Treatments for Migraine in Adults: Future Research Needs. View final report.

No. 36: Multidisciplinary Rehabilitation Programs for Moderate to Severe Traumatic Brain Injury in Adults: Future Research Needs. View final report.

No. 37: Physical Therapy for Knee Pain Secondary to Osteoarthritis: Future Research Needs. View final report.

No. 38: Treatment for Restless Legs Syndrome: Future Research Needs. View final report.

No. 39: Nonoperative and Operative Treatments for Rotator Cuff Tears: Future Research Needs. View final report.

No. 40: Screening for Methicillin-Resistant Staphylococcus aureus (MRSA): Future Research Needs. View final report.

No. 41: Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women: Future Research Needs. View final report.

No. 42: Treatment Strategies for Women With Coronary Artery Disease: Future Research Needs. View final report.

No. 43: Strategies To Prevent Weight Gain in Adults: Future Research Needs. View final report.

No. 44: Long-Term Care for Older Adults: Future Research Needs. View final report.

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